Paracetamol doses and maximum dosage

The paracetamol (also known by the trade name tachipirina) is taken in dosage of 500 mg or 1000 mg, repeatable every 6-8 hours. The maximum daily dose of 4000 mg.

Paracetamol is a drug used as an analgesic (pain reliever) and as an antipyretic (to reduce fever). Paracetamol (acetaminophen) is often called Tachipirina, as this is its most widespread trade name: however, it should not be forgotten that there are numerous other trade names, such as Efferalgan, Acetamol, Codamol and many others.

Paracetamol or acetaminophen (chemical name N-acetyl-para-aminophenol) is the active metabolite of phenacetin.
Paracetamol increases the threshold to painful stimuli, exerting an analgesic effect against pain of different causes and etiology.

It is available without a prescription and is used as a common self-prescription pain reliever (although reimbursement of the paracetamol 1000 mg, if certain conditions exist and if prescribed by prescription). The drug is available in fixed-dose combinations with narcotic and non-narcotic analgesics (including aspirin and other salicylates, barbiturates, caffeine) in preparations for vascular migraine, insomnia, toothache, antihistamines , antitussives, decongestants, expectorants, in cold and flu preparations and in treatments for sore throat.

The most used dosages of paracetamol in single preparation are 500 mg and 1000 mg. Paracetamol represents a valid alternative to aspirin and the others anti-inflammatory such as ibuprofen (momnet, Brufen, Nurofen), ketoprofen (Oki, Ketodol, Artrosilene, Fastum Gel), naproxen (Naprosyl, Momendol, Naproxene), nimesulide (Algimesil, Aulin, Ledoren), diclofenac (Voltaren, Dicloreum) as an analgesic compound antipyretic; however, its anti-inflammatory effects are very low when compared with pure anti-inflammatories.

In fact, despite the paracetamol is indicated in the treatment of pain in patients with non-inflammatory osteoarthritis, it is not an adequate substitute for non-steroidal anti-inflammatory drugs (NotSteroidal Anti-Inflammatory Drugs, NSAIDs) in chronic inflammatory conditions such as rheumatoid arthritis. Paracetamol is well tolerated and is associated with a low incidence of gastrointestinal side effects, which instead affects all other anti-inflammatory drugs, which can cause gastritis and gastric or duodenal ulcers.

However, an acute overdose of Tachipirina can cause severe liver damage and cases of accidental or deliberate intoxication are continuously increasing, especially for those with chronic painful conditions and who take more than 3-4 g of paracetamol for several consecutive days. Chronic use of less than 2 g / day has not been shown to be associated with hepatic dysfunction.

Paracetamol doses and maximum dosage

How much paracetamol can you take it? what is the maximum dose of paracetamol?

Paracetamol maximum permitted dosage

Paracetamol: maximum allowable dosage of Tachipirina for adults and children

The conventional oral dose is 325-650 every 4-6 hours; the total dose should not exceed 4000 mg per day (2000 mg / day for chronic alcoholics). In fact, in Italy the classic formulations of Tachipirina or similar, or generic paracetamol drug are paracetamol 500 mg (used mainly in children or to bring down fever) and paracetamol 1ooo mg, used as a painkiller or for very high or resistant fever.

The formulations of tachipirina and generic paracetamol are mainly in tablets, tablets effervescent od orosoluble, drops and suppositories (particularly useful in children), or vials that can be administered by the way intravenous (used in a hospital setting for patients who need faster pain relieving or antipyretic action, or for those patients who cannot chew and / or swallow).

How much paracetamol you can take it? You can take a maximum of 4 g (4000 mg) of acetaminophen per day. Regarding the maximum dose, however, it should be noted that in 2009 an advisory group of the FDA (Food and Drug Administration) recommended a maximum dose of 2600 mg for paracetamol and a decrease in the maximum single dose from 1000 to 650 mg for commercially available formulations.


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