The anti-DNA antibodies native are autoantibodies, that is antibodies that affect structures of our organism. The most common antibodies to native DNA are double-stranded DNA antibodies (anti double-strain DNA or anti ds-DNA) and anti-single-stranded DNA antibodies (anti single strain DNA or anti ss-DNA).
The antibodies anti ss-DNA are antibodies that recognize and attack the individual filaments of DNA present in the cells causing alteration of replication and damage to the tissues of our organism. Antibodies to ss-DNA are present in approximately 60% of patients with systemic lupus erythematosus (LES).
However, unlike anti ds-DNA, which are quite specific for SLE, anti-ss-DNA are also present in a multitude of other autoimmune diseases, such as autoimmune thyroiditis, the autoimmune hepatitis, there scleroderma, the polymyositis.