The anti-hyaluronidase antibodies they are antibodies targeting a specific protein family, hyaluronidases. Normally the anti hyaluronidase antibodies are present in our blood at values lower than 500 U / ml.
There hyaluronidase it is a hydrolase, an enzyme that hydrolyzes, that is, it degrades, hyalutornic acid.
Due to these capabilities, hydrolase is used in medicine together with other drugs to accelerate and facilitate the diffusion of the latter in the body.
There hyaluronidase it is also secreted by certain types of bacteria such as Staffilococcus aureus, beta-haemolytic streptococci A, B, C, G and Clostridium perfrigens, increasing the permeability of germs in the tissues, and can facilitate the spread of the germ in our body.
The presence of anti-hyaluronidase antibodies is therefore indicative of bacterial infection, especially from Gram + such as Staphylococcus or Streptococcus.
Anti-hyaluronidase antibodies to beta-hemolytic streptococcus A remain longer than anti-streptolysin O and anti-streptokinase in the serum of subjects with streptococcal infection (maximum values: 3,000-15,000 U / ml).