Anti-HHV-6 or anti Human Herpes Virus-6 antibodies


The antibodies anti Herpes Virus 6 (HHV-6) are antibodies directed against the Herpes virus type 6, responsible for sixth disease.

L'Herpes Virus 6 is an agent that causes the sixth disease, also called roseola infantum, exhantema subitum or critical exam, an infectious disease that affects children in the first two years of life (usually between 6 and 24 months), with the infection occurring mainly directly through the passage of infected saliva.

HHV-6 is a Betaherpesvirus and belongs to the Herpesviridae family, which also includes the most common HHV-1 viruses (Human herpes virus 1, the very common cold sores, improperly defined herpes, which affects the mouth and lips) and the HHV-2 (human herpes virus 2, which not infrequently affects the male and female genitals).

Herpes virus 6 is a virus with a particular trophism for the cells of the immune system, in particular i T lymphocytes of type CD4: once infected the organism, it can remain latent for a long time and reactivate only during a moment of particularly intense physical stress or a situation of immunosuppression.
The serological tests used are: immunofluorescence on experimentally infected cells, ELISA, neutralization reactions.

Positivity of antibodies to HHV-6:

In addition to the presence of Human Herpes Virus 6, antibodies to HHV-6 can also be positivized in the presence of other infectious or immunohaematological diseases, such as:

  • Chronic Fatigue Syndrome
  • Sarcoid yes
  • B-cell lymphomas
  • Non-A, non-B, non-C hepatitis
  • Sjògren's syndrome
  • AIDS
  • Cross-reactions with infections from other herpes viruses and particularly from CMV (Cytomegalovirus).

The diagnosis of acute infection requires two sera taken 2-3 weeks apart: a seroconversion indicates a first infection, similarly to the presence of specific IgM.


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