Antibodies to GM Gangliosides

The anti-ganglioside antibodies they are antibodies directed towards some proteins present in our organism, the gangliosides.

THE gangliosides I'm macromolecules glycolipids, consisting of an oligosaccharide with at least one acid sugar linked to a ceramide lipid. They are present in the tissue membranes of the central and peripheral nervous system. Antibodies to GM ganglioside 1 (which stands for Monosial Ganglioside type 1) have been found in the serum of some patients with lower motor neuron syndrome, a disease similar to amyotrophic lateral sclerosis (ALS).

The antibodies are titrated with ELISA and blood titers above 1,350 U / ml are considered specific for the syndrome. In lower motor neuron syndrome they are typically much higher than the 1350 / mL cutoff.

Lower amounts (less than 1,350 U / ml) are non-specific, and can be found in cases of damage to the central nervous system (CNS), such as in multiple sclerosis (multiple sclerosis) or in ALS.

There titration of antibodies it is used to follow the response to therapy. Other antiganglioside antibodies have been identified, but are currently not of clinical use.

Positive anti-GM ganglioside antibodies

Anti-ganglioside antibodies are positive in the following diseases:

  • Lower motor neuron syndrome
  • Multiple sclerosis
  • Amioatrophic lateral sclerosis



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