Anti-Mumps antibodies

The anti-mumps antibodies they are antibodies, measurable in the blood, which are used to diagnose mumps.

There mumps, also called mumps is an epidemic infectious disease caused by a virus belonging to the Paramyxovirus group, whose primary characteristic is the swelling (swelling) of the salivary glands, and in particular of the parotid glands, located behind and below the auricles. The visual appearance of puffy cheeks that ensues justifies the name of mumps.

The infection mumps occurs by direct person-to-person contact, and i symptoms the main ones are fever, sometimes with chills, asthenia (fatigue with general malaise) and swelling of the parotid glands, with pain and difficulty in chewing and swallowing. Fortunately today there is a vaccine, which is administered to infants at 12 months of age in two repeated doses one month apart.

The vaccine can also be carried out by adults, while it is not recommended in immunosuppressed people or in pregnant women.

The diagnosis of mumps is carried out, in addition to clinical analysis, through the dosage of anti mumps antibodies. The search for antibodies to mumps can be done with the classic technique or with ELISA test (enzyme-linked immunosorbent assay).

Classical antibody detection techniques (complement fixation, haemagglutation inhibition, gel hemolysis) are less sensitive than the ELISA. The ELISA test allows to detect, using a single serum sample, IgM (immunoglobulins of type M) up to about 40 days (12-120) from the moment of infection; in the suspicion of parotitic meningitis, the determination of the ratio of IgG (immunoglobulin type G) between CSF and serum can be of help (it is significant if greater than 4).  

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